Ketamine which is a anesthetic has been found to treat bipolar depression and refractory depression treatment and is fast acting
Researchers have struggled to explain how the drug ketamine provides almost immediate relief to many chronically depressed and treatment-resistant patients. While most antidepressants take weeks to reach therapeutic levels, ketamine has been observed to act in hours or days and last for up to 10 days after one dose. This is of great importance for the suicidal patients and important for new research into antidepressants that repair the synapses. Studies have shown the the SSRI’s replace damaged brain cells by neuro-genesis and taking stem-cells and transforming them into adult brain cells; ketamine might open a new field of fast acting antidepressants. Ketamine studies have drawn so much attention, and since the drug is already approved for other uses such as an anesthetic it can already be used (with caution) off label.
Chicago Psychiatrist – Ketamine A Fast Acting Depression Treatment That Many Are Using For Bipolar Depression; Its Use Is Increasing Daily
In fact, scientists have been trying to explain the observation first made at Yale University for well over a decade. New research now suggests that ketamine, normally used as a pediatric anesthetic, helps to regenerate synaptic connections between brain cells damaged by stress and depression. The study, by Yale School of Medicine researchers, is published in the journal Science. Most antidepressants can take weeks to lessen symptoms of depression and do not work at all for one out of every three patients.
Researchers have long sought to improve their understanding of ketamine as the drug works on an entirely different type of neurotransmitter system than current antidepressants. Understanding how ketamine works in the brain could lead to the development of an entirely new class of antidepressants, offering relief for tens of millions of people suffering from chronic depression.
Researchers say the rapid therapeutic response of ketamine in treatment-resistant patients is the biggest breakthrough in depression research in a half century.
Learning how ketamine works in depression treatment will open the doors for new lines of medication management that are fast acting
Understanding how ketamine works is crucial because of the drug’s limitations. The improvement in symptoms, which are evident just hours after ketamine is administered, lasts only a week to 10 days. Methods of delivery and dosing are still in question. Ketamine has been shown to relieve pain caused by somatization disorder which is the bodily manifestation of depression that causes pain.
Unfortunately, in large doses, ketamine can cause short-term symptoms of psychosis, and is abused as the party drug “Special K.” Regardless the benefits of ketamine for treatment of bipolar disorder and treatment refractory depression are said to be the biggest breakthroughs in antidepressants in 50 years and the benefits warrant the risk of abuse.
In their research, Duman and others show that in a series of steps ketamine triggers the release of the neurotransmitter glutamate, which in turn stimulates growth of synapses. Research at Yale has shown that damage of these synaptic connections caused by chronic stress is rapidly reversed by a single dose of ketamine. Researchers say attempts to develop drugs that replicate the effects of ketamine have produced some promising results, but they do not act as quickly as ketamine. As such, investigators continue to study alternatives they hope can duplicate the efficacy and rapid response of ketamine. Read more about the study ketamine for depression
this article regarding ketamine for depression treatment is for informational purposes and not to be used to diagnose or treat any illness, this website Chicago Psychiatrist does not represent any medical doctor or psychiatric practice